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Links for 2022-06-10

  • “Taking the Win over COVID-19”

    Here’s why the US government have decided that “Covid is over” — a PR firm did some market research and decided that the public were bored of it:

    Recognize that people are “worn out” and feeling real harm from the years- long restrictions and take their side. Most Americans have personally moved out of crisis mode. Twice as many voters are now more concerned about COVID’s effect on the economy (49%) than about someone in their family or someone they know becoming infected with the coronavirus (24%). […] Don’t set “COVID zero” as the victory condition. Americans also don’t think victory is COVID Zero. They think the virus is here to stay, and 83% say the pandemic will be over when it’s a mild illness like the flu rather than COVID being completely gone, and 55% prefer that COVID should be treated as an endemic disease. […] Americans also assume they will get COVID: 77% agree that “it is inevitable that most people in the US will eventually get COVID-19”, and 61% of Americans who have never tested positive think they are likely to be infected over the next year. […]
    As jwz says — “In other words: facts don’t matter, only feelings matter, and what’s the point in saving lives if you’re just going to lose the midterms anyway?”

    (tags: america covid-19 us-politics pandemics diseases public-opinion market-research)

  • SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations post recovery

    It’s not just a flu (in hamsters):

    The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying long COVID biology, we compared the short- and long-term systemic responses in the golden hamster following either SARS-CoV-2 or influenza A virus (IAV) infection. Results demonstrated that SARS-CoV-2 exceeded IAV in its capacity to cause permanent injury to the lung and kidney and uniquely impacted the olfactory bulb (OB) and epithelium (OE). Despite a lack of detectable infectious virus, the OB and OE demonstrated myeloid and T cell activation, proinflammatory cytokine production, and an interferon response that correlated with behavioral changes extending a month post viral clearance. These sustained transcriptional changes could also be corroborated from tissue isolated from individuals who recovered from COVID-19. These data highlight a molecular mechanism for persistent COVID-19 symptomology and provide a small animal model to explore future therapeutics.

    (tags: hamsters long-covid covid-19 papers pasc)